Acyclovir release from its composites with silica as a function of the silica matrix modification and the drug loading

被引：3

作者：

Dolinina, Ekaterina S. ^{[1
]}

Akimsheva, Elizaveta Yu ^{[1
]}

Parfenyuk, Elena, V ^{[1
]}

机构：

[1] Russian Acad Sci, GA Krestov Inst Solut Chem, Ivanovo 153045, Russia

来源：

MENDELEEV COMMUNICATIONS | 2021年 / 31卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

silica; acyclovir; silica matrix modification; composites; MESOPOROUS SILICAS; DELIVERY; NANOPARTICLES; CARRIER; GEL;

D O I：

10.1016/j.mencom.2021.09.038

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acyclovir release from its composites with unmodified silica at pH 1.6 and 7.4 follows zero order kinetics for two days. Modification of the silica matrix with phenyl groups leads to dramatic decrease in the drug release level at pH 7.4 compared with pH 1.6 as well as to heterogeneous phase state of acyclovir in the phenyl modified composite with high loading of the drug.

引用

页码：706 / 708

页数：3

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