Efficient complexation of N-acetyl amino acid carboxylates in water by an artificial receptor:: Unexpected cooperativity in the binding of glutamate but not aspartate

被引：52
|
作者：
Schmuck, C [1 ]
Geiger, L [1 ]
机构：
[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 30期
关键词：
D O I：
10.1021/ja052699k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new tris-cation 1 binds N-acetyl amino acid carboxylates in water even at millimolar salt concentrations with Kass ≈ 103 M-1 due to a clustering of electrostatic interactions. Binding is efficient enough to allow a naked-eyed detection using an indicator displacement assay. Furthermore, receptor 1 shows an unexpected 2:1 complex formation with strong positive cooperativity with glutamate but not aspartate. Copyright © 2005 American Chemical Society.
引用
收藏
页码：10486 / 10487
页数：2
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