Low specificity of the Murex fourth-generation HIV enzyme immunoassay in Tanzanian adolescents

被引：14

作者：

Everett, Dean B. ^{[1
]}

Weiss, Helen A. ^{[1
]}

Changalucha, John ^{[2
]}

Anemona, Alessandra ^{[1
]}

Chirwa, Tobias ^{[2
]}

Ross, David A. ^{[1
]}

Watson-Jones, Deborah ^{[1
]}

Parry, John V. ^{[3
]}

Hayes, Richard ^{[1
]}

Mabey, David C. ^{[1
]}

机构：

[1] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England

[2] Natl Inst Med Res, Mwanza, Tanzania

[3] Ctr Infect, Hlth Protect Agcy, London, England

来源：

TROPICAL MEDICINE & INTERNATIONAL HEALTH | 2007年 / 12卷 / 11期

基金：

英国医学研究理事会;

关键词：

HIV tests; Africa; specificity; false positives;

D O I：

10.1111/j.1365-3156.2007.01933.x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

OBJECTIVE To determine the specificity of the Abbott Murex HIV antigen/antibody combination enzyme immunoassay (EIA) for the diagnosis of HIV infection in Tanzania. METHODS A cross-sectional survey of 7333 Tanzanian adolescents and young adults was carried out. Sera testing positive by the Murex assay were further evaluated using a battery of other EIA which detect either antibody to HIV-1 or p24 antigen, and by PCR using pol primers. RESULTS Of the 674 sera testing positive by the Murex assay, only 53 (7.9%) were confirmed. The specificity of the Murex assay was 91.5%. CONCLUSIONS Serological tests for HIV may perform differently in different populations. New diagnostic tests should not be introduced into populations in which they have not been evaluated.

引用

页码：1323 / 1326

页数：4

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