Synthesis and antimicrobial activity of novel thiazolidinones

被引：41

作者：

Sattigeri, VJ ^{[1
]}

Soni, A

Singhal, S

Khan, S

Pandya, M

Bhateja, P

Mathur, T

Rattan, A

Khanna, JM

Mehta, A

机构：

[1] Ranbaxy Res Labs, Dept Med Chem, New Drug Discovery Res, Udyog Vihar Ind Area, R&D 2,Plot 20,Sector 18, Gurgaon 122001, Haryana, India

[2] Ranbaxy Res Labs, Dept Microbiol, New Drug Discovery Res, Udyog Vihar Ind Area, Gurgaon 122001, Haryana, India

来源：

ARKIVOC | 2005年

关键词：

thiazolidin-2-one; thiazolidine-2-thione; iodo-cyclothiocarbamation; antimicrobial activity;

D O I：

10.3998/ark.5550190.0006.205

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel synthesis of thiazolidine-2-thione and thiazolidin-2-one derivatives is described with the iodo-cyclothiocarbamation reaction as the key step for the heterocyclic ring formation. This new method has been applied to the synthesis of thiazolidinones as bioisosteric analogs of Linezolid 2. Antimicrobial properties of two new thiazole derivatives are reported.

引用

页码：46 / 59

页数：14

共 21 条

[1]

Barbachyn MR, 1998, ADV EXP MED BIOL, V456, P219

[2]

Barbachyn MR, 1997, ANTIINFECTIVES RECEN, P15

[3]

BAYLEY H, 1978, TETRAHEDRON LETT, P3633

[4]

Brickner SJ, 1996, CURR PHARM DESIGN, V2, P175

[5] Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant Gram-positive bacterial infections [J].

Brickner, SJ ;

Hutchinson, DK ;

Barbachyn, MR ;

Manninen, PR ;

Ulanowicz, DA ;

Garmon, SA ;

Grega, KC ;

Hendges, SK ;

Toops, DS ;

Ford, CW ;

Zurenko, GE .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (03) :673-679

[6]

Calo V, 1997, GAZZ CHIM ITAL, V127, P283

[7] Changing patterns of infectious disease [J].

Cohen, ML .

NATURE, 2000, 406 (6797) :762-767

[8] SYNTHESIS AND ELABORATION OF HETEROCYCLES VIA IODOCYCLIZATION OF UNSATURATED THIOUREAS [J].

CREEKE, PI ;

MELLOR, JM .

TETRAHEDRON LETTERS, 1989, 30 (33) :4435-4438

[9]

FUGITT RB, 1982, Patent No. 50827

[10] STEREOCONTROLLED AND REGIOCONTROLLED SYNTHESIS OF METHYL N-ACETYL-ALPHA-D-SIBIROSAMINIDE [J].

GEORGES, M ;

MACKAY, D .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (04) :1101-1103

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