Fast Electrical Detection of Carcinoembryonic Antigen Based on AlGaN/GaN High Electron Mobility Transistor Aptasensor

被引：0

作者：

Zhan, Xiang-Mi ^{[1
]}

Wang, Quan ^{[1
]}

Wang, Kun ^{[1
]}

Li, Wei ^{[1
]}

Xiao, Hong-Ling ^{[1
,2
,3
]}

Feng, Chun ^{[1
,3
]}

Jiang, Li-Juan ^{[1
,3
]}

Wang, Cui-Mei ^{[1
,2
,3
]}

Wang, Xiao-Liang ^{[1
,2
,3
]}

Wang, Zhan-Guo ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Inst Semicond, Key Lab Semicond Mat Sci, Beijing 100083, Peoples R China

[2] Univ Chinese Acad Sci, Sch Microelect, Beijing 100049, Peoples R China

[3] Beijing Key Lab Low Dimens Semicond Mat & Devices, Beijing 100083, Peoples R China

来源：

CHINESE PHYSICS LETTERS | 2017年 / 34卷 / 09期

基金：

中国国家自然科学基金;

关键词：

BIOSENSORS; CANCER;

D O I：

10.1088/0256-307X/34/9/097302

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

As one of the most important tumor-associated antigens of colorectal adenocarcinoma, the carcinoembryonic antigen (CEA) threatens human health seriously all over the globe. Fast electrical and highly sensitive detection of the CEA with AlGaN/GaN high electron mobility transistor is demonstrated experimentally. To achieve a low detection limit, the Au-gated sensing area of the sensor is functionalized with a CEA aptamer instead of the corresponding antibody. The proposed aptasensor has successfully detected different concentrations (ranging from 50 picogram/milliliter (pg/ml) to 50 nanogram/milliliter (ng/ml)) of CEA and achieved a detection limit as low as 50 pg/ml at V-ds = 0.5 V. The drain-source current shows a clear increase of 11.5 mu A under this bias.

引用

页数：4

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