SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW HETROCYCLES OBTAINED USING CYANOACETYLATION

被引：12
作者：
Abu-Bakr, Sh. M. [1 ]
El-Shehry, M. F. [2 ]
El-Telbani, E. M. [2 ]
Nawwar, G. A. M. [2 ]
机构：
[1] Natl Res Ctr, Chem Nat & Microbial Prod Dept, Dokki 12622, Egypt
[2] Natl Res Ctr, Green Chem Dept, Dokki 12622, Egypt
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2010年 / 44卷 / 08期
关键词：
cyanoacetylation; thiadiazole; imidazolone; antibacterial and antifungal activities; HETEROCYCLIC SYNTHESIS; ACID;
D O I：
10.1007/s11094-010-0485-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A straightforward synthesis of various nitrogenated heterocycles using a cyanoacetylating reagent from cyanoacetic acid and acetic anhydride is described. Biological testing of the synthesized compounds for their antibacterial and antifungal activities has been carried out.
引用
收藏
页码：433 / 437
页数：5
相关论文
共 20 条
  • [1] Allam YA, 2001, J CHEM RES-S, P346
  • [2] Synthesis and biological effects of novel 2-amino-3-naphthoylthiophenes as allosteric enhancers of the A1 adenosine receptor
    Baraldi, PG
    Romagnoli, R
    Pavani, MG
    Nuñez, MD
    Tabrizi, MA
    Shryock, JC
    Leung, E
    Moorman, AR
    Uluoglu, C
    Iannotta, V
    Merighi, S
    Borea, PA
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (05) : 794 - 809
  • [3] CELLTECH, 2000, Patent No. 2000078731
  • [4] Collins A.H., 1976, Microbiological Methods, Vsecond
  • [5] Cruickshank R., 1975, Medicinal Microbiology, VII, P196
  • [6] EBY JC, 1957, J AM CHEM SOC, V79, P723
  • [7] Meldrum's acid in heterocyclic synthesis:: azoles incorporating a 2,4-dichlorophenoxy moiety with anticipated molluscicidal activity
    El-Telbani, Emad M.
    El Shehry, Mohamed F.
    Nawwar, Galal A. M.
    [J]. MONATSHEFTE FUR CHEMIE, 2008, 139 (06): : 685 - 689
  • [8] 2-AMINO-THIOPHENE AUS METHYLENAKTIVEN NITRILEN CARBONYLVERBINDUNGEN UND SCHWEFEL
    GEWALD, K
    SCHINKE, E
    BOTTCHER, H
    [J]. CHEMISCHE BERICHTE-RECUEIL, 1966, 99 (01): : 94 - &
  • [9] Hayashi H, 1997, HETEROCYCLES, V45, P1647
  • [10] IRINA OZ, 2005, BIOORGAN MED CHEM, V15, P5483
12