The first demonstration of lactic acid in human blood in shock by Johann Joseph Scherer (1814-1869) in January 1843

被引：92
作者：
Kompanje, E. J. O. [1 ]
Jansen, T. C. [1 ]
van der Hoven, B. [1 ]
Bakker, J. [1 ]
机构：
[1] Erasmus MC Univ, Med Ctr, Dept Intens Care, NL-3000 CA Rotterdam, Netherlands
来源：
INTENSIVE CARE MEDICINE | 2007年 / 33卷 / 11期
关键词：
lactic acid; lactate; shock; leukaemia; Johann Joseph Scherer; historical article;
D O I：
10.1007/s00134-007-0788-7
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Lactic acid was first found and described in sour milk by Karl Wilhelm Scheele (1742-1786) in 1780. The German physician-chemist Johann Joseph Scherer (1841-1869) demonstrated the occurrence of lactic acid in human blood under pathological conditions in 1843 and 1851. In this article we honour the forgotten observations by Scherer and describe the influence of Scherer's finding on further research on lactic acid at the end of the 19th century. We conclude that Scherer's 1843 case reports should be cited as the first description of lactic acid in human blood after death and also as the first demonstration of lactic acid as a pathological finding in septic and haemorrhagic shock. Carl Folwarczny was, in 1858, the first to demonstrate lactic acid in blood in a living patient.
引用
收藏
页码：1967 / 1971
页数：5
相关论文
共 32 条
[1]  
Araki T., 1891, Z PHYSL CHEM, V15, P335
[2]  
ARAKI T, 1891, Z PHYSL CHEM, V15, P546
[3]  
Araki T., 1892, Z PHYSL CHEM, V16, P453
[4]  
ARAKI T, 1892, Z PHYSL CHEM, V16, P201
[5]  
Astrup P., 1986, HIST BLOOD GASES ACI
[6]   Increased blood lacate levels: an important warning signal in surgical practice [J].
Bakker, J ;
de Lima, AP .
CRITICAL CARE, 2004, 8 (02) :96-98
[7]  
BERLINERBLAU M, 1877, N-S ARCH PHARMACOL, V23, P333
[8]  
BERZELIUS JJ, 1847, C R HEBDOM SEANCES A, V24, P69
[9]  
BERZELIUS JJ, 1806, FORELASNINGAR DJURKE
[10]  
BUTTNER J, 1978, J CLIN CHEM CLIN BIO, V16, P478
1234