De novo Thrombotic Microangiopathy Induced by Cytomegalovirus Infection Leading to Renal Allograft Loss

被引：22

作者：

De Keyzer, Kristel ^{[1
]}

Van Laecke, Steven ^{[1
]}

Peeters, Patrick ^{[1
]}

Vanholder, Raymond ^{[1
]}

机构：

[1] Ghent Univ Hosp, Div Renal, BE-9000 Ghent, Belgium

来源：

AMERICAN JOURNAL OF NEPHROLOGY | 2010年 / 32卷 / 05期

关键词：

Cytomegalovirus infection; Hemolytic-uremic syndrome; Kidney transplantation; Thrombotic microangiopathy; HEMOLYTIC-UREMIC SYNDROME; KIDNEY-TRANSPLANTATION; THROMBOCYTOPENIC PURPURA; MUTATION; THERAPY;

D O I：

10.1159/000321328

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

After kidney transplantation, thrombotic microangiopathy (TMA) can occur de novo or as recurrent disease. Risk factors for de novo posttransplant TMA include ischemia-reperfusion injury, immunosuppressive drugs, viral infections, acute humoral rejection, and complement gene abnormalities. Cytomegalovirus infection as a trigger for posttransplant TMA in kidney transplant recipients has only been reported in 7 cases, all of them between 4 weeks and 8 years after transplantation. We describe a new case of de novo TMA in association with cytomegalovirus infection 25 years after kidney transplantation. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：491 / 496

页数：6

共 17 条

[1] Guideline for the investigation and initial therapy of diarrhea-negative hemolytic uremic syndrome [J].

Ariceta, Gema ;

Besbas, Nesrin ;

Johnson, Sally ;

Karpman, Diana ;

Landau, Daniel ;

Licht, Christoph ;

Loirat, Chantal ;

Pecoraro, Carmine ;

Taylor, C. Mark ;

Van de Kar, Nicole ;

VandeWalle, Johan ;

Zimmerhackl, Lothar B. .

PEDIATRIC NEPHROLOGY, 2009, 24 (04) :687-696

[2] A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders [J].

Besbas, N. ;

Karpman, D. ;

Landau, D. ;

Loirat, C. ;

Proesmans, W. ;

Remuzzi, G. ;

Rizzoni, G. ;

Taylor, C. M. ;

Van de Kar, N. ;

Zimmerhackl, L. B. .

KIDNEY INTERNATIONAL, 2006, 70 (03) :423-431

[3] Immunobiology of Human Cytomegalovirus: from Bench to Bedside [J].

Crough, Tania ;

Khanna, Rajiv .

CLINICAL MICROBIOLOGY REVIEWS, 2009, 22 (01) :76-+

[4] TRANSPLANT-ASSOCIATED THROMBOTIC MICROANGIOPATHY - THE ROLE OF IGG ADMINISTRATION AS INITIAL THERAPY [J].

HOCHSTETLER, LA ;

FLANIGAN, MJ ;

LAGER, DJ .

AMERICAN JOURNAL OF KIDNEY DISEASES, 1994, 23 (03) :444-450

[5] Thrombotic microangiopathy in association with cytomegalovirus infection in a renal transplant patient - A new treatment strategy [J].

Jeejeebhoy, FM ;

Zaltzman, JS .

TRANSPLANTATION, 1998, 65 (12) :1645-1648

[6] Outcome of plasma exchange therapy in thrombotic microangiopathy after renal transplantation [J].

Karthikeyan, V ;

Parasuraman, R ;

Shah, V ;

Vera, E ;

Venkat, KK .

AMERICAN JOURNAL OF TRANSPLANTATION, 2003, 3 (10) :1289-1294

[7] International Consensus Guidelines on the Management of Cytomegalovirus in Solid Organ Transplantation [J].

Kotton, Camille N. ;

Kumar, Deepali ;

Caliendo, Angela M. ;

Asberg, Anders ;

Chou, Sunwen ;

Snydman, David R. ;

Allen, Upton ;

Humar, Atul .

TRANSPLANTATION, 2010, 89 (07) :779-795

[8] Complement mutation-associated de novo thrombotic microangiopathy following kidney transplantation [J].

Le Quintrec, M. ;

Lionet, A. ;

Kamar, N. ;

Karras, A. ;

Barbier, S. ;

Buchler, M. ;

Fakhouri, F. ;

Provost, F. ;

Fridiman, W. H. ;

Thervet, E. ;

Legendre, C. ;

Zuber, J. ;

Fremeaux-Bacchi, V. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2008, 8 (08) :1694-1701

[9]

NOEL C, 1992, ANN MED INTERNE, V143, P33

[10] Thrombotic Microangiopathy After Kidney Transplantation [J].

Noris, M. ;

Remuzzi, G. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2010, 10 (07) :1517-1523

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