N-heterocyclic carbene catalysed asymmetric cross-benzoin reactions of heteroaromatic aldehydes with trifluoromethyl ketones

被引：119

作者：

Enders, Dieter ^{[1
]}

Grossmann, Andre ^{[1
]}

Fronert, Jeanne ^{[1
]}

Raabe, Gerhard ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 34期

关键词：

SALT; ADDITIONS; DONOR;

D O I：

10.1039/c0cc02013c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new triazolium salt derived N-heterocyclic carbene catalyses an asymmetric cross-benzoin-type reaction of heteroaromatic aldehydes and various trifluoromethyl ketones in good to excellent yields (69-96%) and moderate to good enantio-selectivities (ee = 39-85%). Up to 99% ee can be achieved by recrystallisation.

引用

页码：6282 / 6284

页数：3

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