The Mohawk homeobox gene is a critical regulator of tendon differentiation

被引：234

作者：

Ito, Yoshiaki ^{[1
]}

Toriuchi, Naoya ^{[1
]}

Yoshitaka, Teruhito ^{[1
]}

Ueno-Kudoh, Hiroe ^{[1
]}

Sato, Tempei ^{[1
]}

Yokoyama, Shigetoshi ^{[1
]}

Nishida, Keiichiro ^{[2
]}

Akimoto, Takayuki ^{[3
]}

Takahashi, Michiko ^{[1
]}

Miyaki, Shigeru ^{[1
]}

Asahara, Hiroshi ^{[1
]}

机构：

[1] Natl Res Inst Child Hlth & Dev, Dept Syst BioMed, Tokyo 1578535, Japan

[2] Okayama Univ, Grad Sch Med & Dent, Dept Human Morphol Sci Funct Recovery & Reconstru, Okayama 7008558, Japan

[3] Univ Tokyo, Grad Sch Med, Ctr Dis Biol & Integrat Med, Lab Regenerat Med Engn, Tokyo 1130033, Japan

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 23期

基金：

日本科学技术振兴机构;

关键词：

COLLAGEN FIBRIL; SKIN FRAGILITY; DEFICIENT MICE; EXPRESSION; SCLERAXIS; MOUSE; CELL; IDENTIFICATION; PROLIFERATION; MORPHOGENESIS;

D O I：

10.1073/pnas.1000525107

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mohawk(Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx(-/-) mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx(-/-) mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx(-/-) tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells.

引用

页码：10538 / 10542

页数：5

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