Meta-analysis for cyclin E in lung cancer survival

被引：33

作者：

Huang, Li-nian ^{[1
]}

Wang, Dong-sheng ^{[1
,2
]}

Chen, Yu-qing ^{[1
]}

Li, Wei ^{[1
]}

Hu, Feng-dan ^{[3
]}

Gong, Bei-lei ^{[1
]}

Zhao, Cheng-Ling ^{[1
]}

Jia, Wei ^{[1
]}

机构：

[1] Bengbu Med Coll, Dept Respirat, Affiliated Hosp 1, Anhui Prov Key Lab Clin Basic Res Resp Dis, Bengbu 233004, Anhui, Peoples R China

[2] Anhui Prov Hosp, Dept Respirat, Hefei, Peoples R China

[3] Wuhe Cty Hosp, Dept Respirat, Wuhe, Anhui, Peoples R China

来源：

CLINICA CHIMICA ACTA | 2012年 / 413卷 / 7-8期

关键词：

Lung cancer; Cyclin E; Prognosis; Meta-analysis; POTENTIAL PROGNOSTIC MARKER; OF-THE-LITERATURE; CELL-CYCLE; BREAST-CANCER; E EXPRESSION; CARCINOMAS; PROLIFERATION; OVEREXPRESSION; REGULATORS; TRIALS;

D O I：

10.1016/j.cca.2011.12.020

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: To assess the prognosis value of cyclin E expression in survival of patients with lung cancer (LC), we performed a systematic review of the literature with meta-analysis. Methods: Electronic databases were used to identify published studies before August 2011. Pooled hazard ratio (HR) with 95% confidence interval (95% CI) was used to estimate the strength of the association of cyclin E expression with survival of LC patients. Heterogeneity and publication bias were also assessed. Results: Fourteen studies (2606 cases) were eligible and subjected to analysis. Cyclin E over-expression was found to be a strong predictor of poor prognosis in LC patients (HR: 1.38, 95% CI: 1.07-1.79; P = 0.014). When only non-small cell lung cancer (NSCLC) was considered, the combined HR was 1.53 (95% Cl: 1.19-1.97, P = 0.001). A significant association was also evident when the analysis was limited to studies involving adenocarcinoma (AD), but not squamous cell carcinoma (SQ). Publication bias was absent. Sensitivity analyses suggested that the summary statistics obtained should approximate the actual average. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：663 / 668

页数：6

共 37 条

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