Mild dynamic kinetic resolution of amines by coupled visible-light photoredox and enzyme catalysis

被引：30

作者：

Yang, Qiong ^{[1
]}

Zhao, Fengqian ^{[1
]}

Zhang, Na ^{[1
]}

Liu, Mingke ^{[1
]}

Hu, Huanhuan ^{[1
]}

Zhang, Jingjie ^{[1
]}

Zhou, Shaolin ^{[1
]}

机构：

[1] Cent China Normal Univ, Coll Chem, CCNU uOttawa Joint Res Ctr, Key Lab Pesticide & Chem Biol,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 100期

基金：

中国国家自然科学基金;

关键词：

2+2 PHOTOCYCLOADDITION REACTIONS; ALKALINE-EARTH SUPPORTS; DUAL-CATALYSIS; ENANTIOSELECTIVE SYNTHESIS; MESOCELLULAR FOAM; ALPHA-ALKYLATION; RADICAL CATIONS; TERTIARY-AMINES; RACEMIZATION; PD;

D O I：

10.1039/c8cc07990k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we described photoenzymatic dynamic kinetic resolution (DKR) of amines under mild conditions. The racemization of amines via a photoredox-mediated hydrogen atom transfer (HAT) protocol in conjunction with an enzyme catalyst to achieve the DKR of amines allows a variety of primary amines to be converted into a single enantiomer in high yield and with excellent enantioselectivity. Notably, this protocol can also be extended to 1,4-diamine derivatives with high levels of diastereo-and enantioselectivity.

引用

页码：14065 / 14068

页数：4

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