Association of the metabolic syndrome with intracranial atherosclerotic stroke

被引：136

作者：

Bang, OY ^{[1
]}

Kim, JW ^{[1
]}

Lee, JH ^{[1
]}

Lee, MA ^{[1
]}

Lee, PH ^{[1
]}

Joo, IS ^{[1
]}

Huh, K ^{[1
]}

机构：

[1] Ajou Univ, Dept Neurol, Sch Med, Suwon 442749, South Korea

来源：

NEUROLOGY | 2005年 / 65卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

D O I：

10.1212/01.wnl.0000168862.09764.9f

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To investigate the impact of metabolic syndrome (MetSD) on the development of intracranial atherosclerotic stroke, the authors evaluated the components of the MetSD in 512 patients with stroke. The MetSD was observed most frequently in patients with intracranial atherosclerosis (p = 0.007). In multiple regression analysis, the MetSD, but not conventional risk factors, was independently associated with intracranial atherosclerosis (p = 0.005). The results suggest that treatment of metabolic abnormalities may be an important prevention strategy for intracranial atherosclerosis.

引用

页码：296 / 298

页数：3

共 10 条

[1] Endothelial dysfunction in cardiovascular diseases - The role of oxidant stress [J].

Cai, H ;

Harrison, DG .

CIRCULATION RESEARCH, 2000, 87 (10) :840-844

[2] Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) [J].

Cleeman, JI ;

Grundy, SM ;

Becker, D ;

Clark, LT ;

Cooper, RS ;

Denke, MA ;

Howard, WJ ;

Hunninghake, DB ;

Illingworth, DR ;

Luepker, RV ;

McBride, P ;

McKenney, JM ;

Pasternak, RC ;

Stone, NJ ;

Van Horn, L ;

Brewer, HB ;

Ernst, ND ;

Gordon, D ;

Levy, D ;

Rifkind, B ;

Rossouw, JE ;

Savage, P ;

Haffner, SM ;

Orloff, DG ;

Proschan, MA ;

Schwartz, JS ;

Sempos, CT ;

Shero, ST ;

Murray, EZ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19) :2486-2497

[3] Age-related effects on atherogenesis and scavenger enzymes of intracranial and extracranial arteries in men without classic risk factors for atherosclerosis [J].

D'Armiento, FP ;

Bianchi, A ;

de Nigris, F ;

Capuzzi, DM ;

D'Armiento, MR ;

Crimi, G ;

Abete, P ;

Palinski, W ;

Condorelli, M ;

Napoli, C .

STROKE, 2001, 32 (11) :2472-2478

[4] The metabolic syndrome and antioxidant concentrations - Findings from the Third National Health and Nutrition Examination Survey [J].

Ford, ES ;

Mokdad, AH ;

Giles, WH ;

Brown, DW .

DIABETES, 2003, 52 (09) :2346-2352

[5] The metabolic syndrome and risk of major coronary events in the Scandinavian simvastatin survival study (4S) and the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS) [J].

Girman, CJ ;

Rhodes, T ;

Mercuri, M ;

Pyörälä, K ;

Kjekshus, J ;

Pedersen, TR ;

Beere, PA ;

Gotto, AM ;

Clearfield, M .

AMERICAN JOURNAL OF CARDIOLOGY, 2004, 93 (02) :136-141

[6] Prevalence of the metabolic syndrome in patients with coronary heart disease, cerebrovascular disease, peripheral arterial disease or abdominal aortic aneurysm [J].

Gorter, PM ;

Olijhoek, JK ;

van der Graaf, Y ;

Algra, A ;

Rabelink, TJ ;

Visseren, FLJ .

ATHEROSCLEROSIS, 2004, 173 (02) :363-369

[7]

HULTHE J, 2000, ARTERIOSCLER THROMB, V20, P2014

[8]

Inoue, 2000, STEERING COMMITTEE W

[9] Clustering of procoagulation, inflammation, and fibrinolysis variables with metabolic factors in insulin resistance syndrome [J].

Sakkinen, PA ;

Wahl, P ;

Cushman, M ;

Lewis, MR ;

Tracy, RP .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2000, 152 (10) :897-907

[10] Plasma lipid profile and incident ischemic stroke - The Atherosclerosis Risk in Communities (ARIC) Study [J].

Shahar, E ;

Chambless, LE ;

Rosamond, WD ;

Boland, LL ;

Ballantyne, CM ;

McGovern, PG ;

Sharrett, AR .

STROKE, 2003, 34 (03) :623-631

← 1 →