BEN: a novel domain in chromatin factors and DNA viral proteins

被引：84

作者：

Abhiman, Saraswathi ^{[1
]}

Iyer, Lakshminarayan M. ^{[1
]}

Aravind, L. ^{[1
]}

机构：

[1] NIH, Natl Lib Med, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA

来源：

BIOINFORMATICS | 2008年 / 24卷 / 04期

关键词：

D O I：

10.1093/bioinformatics/btn007

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We report a previously uncharacterized alpha-helical module, the BEN domain, in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Contextual analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organization and transcription. The presence of BEN domains in a poxviral early virosomal protein and in polydnaviral proteins also suggests a possible role for them in organization of viral DNA during replication or transcription.

引用

页码：458 / 461

页数：4

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