The influence of the ligand chelate effect on iron-amine-catalysed Kumada cross-coupling

被引：29

作者：

Bedford, Robin B. ^{[1
]}

Brenner, Peter B. ^{[1
]}

Elorriaga, David ^{[1
]}

Harvey, Jeremy N. ^{[2
]}

Nunn, Joshua ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] Univ Leuven, KU Leuven, Dept Chem, Quantum Chem & Phys Chem Sect, Celestijnenlaan 200F,Box 2404, Leuven, Belgium

来源：

DALTON TRANSACTIONS | 2016年 / 45卷 / 40期

基金：

英国工程与自然科学研究理事会;

关键词：

ARYL GRIGNARD-REAGENTS; ALKYL-HALIDES; ALKENYL HALIDES; COMPLEXES; DERIVATIVES; BENZYL; TMEDA;

D O I：

10.1039/c6dt01823h

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The application of a variety of iron complexes with chelating amine ligands as pre-catalysts in the representative cross-coupling of 4-tolylmagnesium bromide with cyclohexyl bromide was investigated. The results from this study indicate the performance of the pre-catalyst is inversely proportional to the strength of the chelate or macrocyclic effect of the amine ligand, as determined by the propensity of the ligand to be displaced from the iron centre by reaction with excess benzyl magnesium chloride. The findings from this study are consistent with a catalytic cycle wherein the chelating amine ligand is not coordinated to the iron centre during turnover.

引用

页码：15811 / 15817

页数：7

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