Risk of Autism Associated With General Anesthesia During Cesarean Delivery: A Population-Based Birth-Cohort Analysis

被引:57
作者
Chien, Li-Nien [1 ]
Lin, Hsiu-Chen [2 ,3 ]
Shao, Yu-Hsuan Joni [4 ]
Chiou, Shu-Ti [5 ,6 ]
Chiou, Hung-Yi [7 ]
机构
[1] Taipei Med Univ, Coll Publ Hlth & Nutr, Sch Hlth Care Adm, Taipei 110, Taiwan
[2] Taipei Med Univ, Coll Med, Sch Med, Dept Pediat, Taipei 110, Taiwan
[3] Taipei Med Univ Hosp, Dept Lab Med, Taipei, Taiwan
[4] Taipei Med Univ, Grad Inst Biomed Informat, Taipei 110, Taiwan
[5] Minist Hlth & Welf, Hlth Promot Adm, Taipei, Taiwan
[6] Natl Yang Ming Univ, Inst Publ Hlth, Sch Med, Taipei 112, Taiwan
[7] Taipei Med Univ, Sch Publ Hlth, Coll Publ Hlth & Nutr, Taipei 110, Taiwan
关键词
Autism; Cesarean delivery; Obstetric anesthesia; Population-based birth cohort; DEVELOPMENTAL DISORDERS; PROPENSITY-SCORE; EARLY EXPOSURE; PATERNAL AGE; MODE; DISABILITIES; MANAGEMENT; DIAGNOSIS; CHILDREN; OUTCOMES;
D O I
10.1007/s10803-014-2247-y
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
The rates of Cesarean delivery (C-section) have risen to > 30 % in numerous countries. Increased risk of autism has been shown in neonates delivered by C-section. This study examined the incidence of autism in neonates delivered vaginally, by C-section with regional anesthesia (RA), and by C-section with general anesthesia (GA) to evaluate the risk of autism associated with C-section and obstetric anesthesia. During a mean follow-up of 4.3 years, the incidence of autism was higher in neonates delivered by C-section with GA than in neonates delivered vaginally, with an adjusted risk of 1.52 (95 % confidence interval 1.18-1.94). However, the adjusted risk of autism in neonates delivered by C-section with RA and in neonates delivered vaginally was nonsignificantly different.
引用
收藏
页码:932 / 942
页数:11
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