3D printed polylactic acid nanocomposite scaffolds for tissue engineering applications

被引：72
作者：
Alam, Fahad [1 ]
Varadarajan, K. M. [2 ,3 ]
Kumar, S. [1 ]
机构：
[1] Khalifa Univ, Dept Mech Engn, Masdar Campus, Abu Dhabi, U Arab Emirates
[2] Massachusetts Gen Hosp, Dept Orthopaed Surg, Harris Orthopaed Lab, 55 Fruit St, Boston, MA 02114 USA
[3] Harvard Med Sch, Dept Orthopaed Surg, A-111,25 Shattuck St, Boston, MA 02115 USA
来源：
POLYMER TESTING | 2020年 / 81卷
关键词：
3D printing; PLA nanocomposites; Biodegradation; Bioactivity; Stiffness; BIOMATERIALS; FABRICATION; POLYMER; PLA; PERFORMANCE; BIOCOMPATIBILITY; COMPOSITES;
D O I：
10.1016/j.polymertesting.2019.106203
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
In this study, biodegradable polylactic acid (PLA) and PLA nanocomposite scaffolds reinforced with magnetic and conductive fillers, were processed via fused filament fabrication additive manufacturing and their bioactivity and biodegradation characteristics were examined. Porous 3D architectures with 50% bulk porosity were 3D printed, and their physicochemical properties were evaluated. Thermal analysis confirmed the presence of similar to 18 wt% of carbon nanostructures (CNF and GNP; nowonwards CNF) and similar to 37 wt% of magnetic iron oxide (Fe2O3) particles in the filaments. The in vitro degradation tests of scaffolds showed porous and fractured struts after 2 and 4 weeks of immersion in DMEM respectively, although a negligible weight loss is observed. Greater extent of degradation is observed in PLA with magnetic fillers followed by PLA with conductive fillers and neat PLA. In vitro bioactivity study of scaffolds indicate enhancement from similar to 2.9% (PLA) to similar to 5.32% (PLA/CNF) and similar to 3.12% (PLA/Fe2O3). Stiffness calculated from the compression tests showed decrease from similar to 680 MPa (PLA) to 533 MPa and 425 MPa for PLA/CNF and PLA/Fe2O3 respectively. Enhanced bioactivity and faster biodegradation response of PLA nanocomposites with conductive fillers make them a potential candidate for tissue engineering applications such as scaffold bone replacement and regeneration.
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页数：9
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