Synthesis and DNA binding properties of DNA-PNA chimeras

被引：4

作者：

Barone, G

De Napoli, L

Di Fabio, G

Erra, E

Giancola, C

Messere, A

Montesarchio, D

Petraccone, L

Piccialli, G

机构：

[1] Univ Naples Federico II, Dipartimento Chim Organ & Biochim, I-80126 Naples, Italy

[2] Univ Naples Federico II, Dipartimento Chim, I-80126 Naples, Italy

[3] Seconda Univ Napoli, Dipartimento Sci Ambientali, Caserta, Italy

[4] Dipartimento Chim Sostanze Nat, Naples, Italy

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 5-8期

关键词：

DNA-PNA chimera; triplex; UV- and CD-monitored thermal stability;

D O I：

10.1081/NCN-120022743

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A systematic study to evaluate the ability of 5'-DNA-3'-p-(N)-PNA-(C) chimeras to form triple helix structures has been undertaken. Preliminary results carried out on a 16-mer chimera with three PNA monomers at the 3'-end showed the formation of a stable DNA-PNA/DNA/DNA triplex, having similar conformational behaviour to a canonical DNA/DNA/DNA triplex.

引用

页码：1089 / 1091

页数：3

共 4 条

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[4]

Uhlmann E, 1998, ANGEW CHEM INT EDIT, V37, P2797

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