Transition-Metal-Free Decarboxylative Coupling Reactions for the Synthesis of Propargyl Alcohols

被引：9
|
作者：
Irudayanathan, Francis Mariaraj [1 ]
Kim, Jimin [1 ]
Song, Kwang Ho [2 ]
Lee, Sunwoo [1 ]
机构：
[1] Chonnam Natl Univ, Dept Chem, Gwangju 61186, South Korea
[2] Korea Univ, Dept Chem & Biol Engn, Seoul 02841, South Korea
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 5卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
aldehydes; alkynyl carboxylic acid; decarboxylative coupling; ketones; propargyl alcohol; TRIFLUOROMETHYL KETONES; CATALYTIC ALKYNYLATION; CARBOXYLIC-ACIDS; TERMINAL ALKYNES; ALDEHYDES; EFFICIENT; AMINES; WATER; NANOPARTICLES; HETEROCYCLES;
D O I：
10.1002/ajoc.201600265
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Propargyl alcohols have been directly synthesized by decarboxylative coupling reactions with an alkynyl carboxylic acid and an aldehyde/ketone in the absence of a transition-metal catalyst. When the decarboxylative coupling reaction was conducted with Cs2CO3 in DMSO, the desired propargyl alcohols were formed in good yield. In addition, the reactions with 2,2,2-trifluoroacetophenone and aryl alkynyl carboxylic acids gave trifluoromethylated propargyl alcohols.
引用
收藏
页码：1148 / 1154
页数：7
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