Anti-Hyperuricemic and Nephroprotective Effects of Rhein in Hyperuricemic Mice

被引：67

作者：

Meng, Zhaoqing ^{[1
,2
]}

Yan, Yunxia ^{[1
]}

Tang, Zhaohui ^{[2
]}

Guo, Changrun ^{[1
]}

Li, Na ^{[2
]}

Huang, Wenzhe ^{[2
]}

Ding, Gang ^{[2
]}

Wang, Zhenzhong ^{[2
]}

Xiao, Wei ^{[2
]}

Yang, Zhonglin ^{[1
]}

机构：

[1] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China

[2] Jiangsu Kanion Pharmaceut Co Ltd, Lianyungang 222001, Peoples R China

来源：

PLANTA MEDICA | 2015年 / 81卷 / 04期

关键词：

rhein; hyperuricemia; nephroprotective effect; xanthine oxidase; uricosuric action; interleukin-1; beta; transforming growth factor-beta 1; RENAL INTERSTITIAL FIBROSIS; URIC-ACID NEPHROPATHY; GOUT; RATS; INFLAMMATION; APOPTOSIS; CRYSTALS; STRESS; CANCER; ROLES;

D O I：

10.1055/s-0034-1396241

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Hyperuricemia has been considered to be a key risk factor for kidney disease. The formation of uric acid crystals in the kidney further stimulates an intensive inflammatory response. Rhein possesses various pharmacological activities, including anti-inflammatory, antioxidative, antitumor, purgative effects, and so on. To our knowledge, no previous work has been reported about the therapeutic effect of rhein on urate nephropathy. In this study, a model of hyperuricemia and nephropathy induced by adenine and ethambutol in mice was established. Meanwhile, the potential beneficial effects and mechanisms of rhein on hyperuricemia and nephropathy were also investigated. The results demonstrated that rhein significantly decreased the serum uric acid level by inhibiting the xanthine oxidase activity and increasing the excretion of urinary uric acid. In addition, rhein also markedly improved kidney damage related to hyperuricemia. Further investigation indicated that rhein improved the symptoms of nephropathy through decreasing the production of proinflammatory cytokines, including interleukin 1 beta, prostaglandin E-2, and tumor necrosis factor-alpha and inhibiting the expression of transforming growth factor-beta 1. The present study suggests that rhein may have a considerable potential for development as an anti-hyperuricemic and nephroprotective agent for clinical application.

引用

页码：279 / 285

页数：7

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