Structure function relationships of glycoprotein hormones and their subunits' ancestors

被引：70
作者：
Cahoreau, Claire [1 ]
Klett, Daniele [1 ]
Combarnous, Yves [1 ]
机构：
[1] INRA, CNRS, PRC, F-37380 Nouzilly, France
来源：
FRONTIERS IN ENDOCRINOLOGY | 2015年 / 6卷
关键词：
glycoprotein hormones; luteinizing hormone; follicle-stimulating hormone; thyroid-stimulating hormone; evolution; molecular; structure activity relationship; FOLLICLE-STIMULATING-HORMONE; HUMAN CHORIONIC-GONADOTROPIN; EQUINE LUTEINIZING-HORMONE; HUMAN FSH RECEPTOR; FREE-ALPHA MOLECULES; ACTIVE SINGLE-CHAIN; BETA-SUBUNIT; CIRCULAR-DICHROISM; THYROTROPIN RECEPTOR; TSH RECEPTOR;
D O I：
10.3389/fendo.2015.00026
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Glycoprotein hormones (GPHs) are the most complex molecules with hormonal activity. They exist only in vertebrates but the genes encoding their subunits' ancestors are found in most vertebrate and invertebrate species although their roles are still unknown. In the present report, we review the available structural and functional data concerning GPHs and their subunits' ancestors.
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页数：14
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