Non-isomerized C-telopeptide fragments are highly sensitive markers for monitoring disease activity and treatment efficacy in Paget's disease of bone

被引：30
作者：
Alexandersen, P
Peris, P
Guañabens, N
Byrjalsen, I
Alvarez, L
Solberg, H
Cloos, PAC
机构：
[1] Ctr Clin & Basic Res, DK-2750 Ballerup, Denmark
[2] Univ Barcelona, Serv Rheumatol, Hosp Clin, Barcelona, Spain
[3] Inst Invest Biomed August Pi I Sunyer, Metab Bone Dis Unit, Barcelona, Spain
[4] Nord Biosci, Herlev, Denmark
[5] Univ Barcelona, Serv Clin Biochem, Hosp Clin, Barcelona, Spain
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2005年 / 20卷 / 04期
关键词：
Paget's disease; bone turnover markers; collagen; aging; bisphosphonates;
D O I：
10.1359/JBMR.041212
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A new resorption assay measuring non-isomerized collagen type I C-telopeptide fragments (alpha-alpha CTX) was evaluated in a cohort comprising 32 Pagetic patients and 48 healthy controls. alpha-alpha CTX was found to be a sensitive marker for assessing disease activity and monitoring treatment efficacy in Paget's disease of bone compared with isomerized CTX (beta-beta CTX) and a number of other established bone turnover markers.
引用
收藏
页码：588 / 595
页数：8
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