Changes in pro/antioxidant balance in smoking and non-smoking pregnant women with intrauterine growth restriction

被引：35
作者：
Bizon, Anna [1 ]
Milnerowicz-Nabzdyk, Ewa [2 ]
Zalewska, Marta [1 ]
Zimmer, Mariusz [2 ]
Milnerowicz, Halina [1 ]
机构：
[1] Wroclaw Med Univ, Dept Biomed & Environm Anal, PL-50355 Wroclaw, Poland
[2] Wroclaw Med Univ, Dept & Clin Gynaecol Obstet & Neonatol 2, PL-50556 Wroclaw, Poland
来源：
REPRODUCTIVE TOXICOLOGY | 2011年 / 32卷 / 03期
关键词：
8-Hydroxydeoxyguanosine; Cu/Zn superoxide dismutase; Glutathione; Glutathione peroxidase; Heavy metals; Malondialdehyde; Metallothionein; OXIDATIVE STRESS; ERYTHROCYTE METALLOTHIONEIN; MATERNAL SMOKING; UMBILICAL-CORD; BIRTH-WEIGHT; CADMIUM; ZINC; EXPOSURE; TOBACCO; MALONDIALDEHYDE;
D O I：
10.1016/j.reprotox.2011.08.007
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The aim of this study was to investigate the influence of cigarette smoking on the pro/antioxidant balance in pregnant women with intrauterine growth restriction (IUGR). The studies have shown a 2-fold increase of Cd concentration in blood of women with IUGR in labour and a 10-fold increase in smoking pregnant women with IUGR. The increase of malondialdehyde concentration in plasma and 8-hydroxydeoxyguanosine in serum and Cu/Zn superoxide dismutase activity in erythrocyte lysate of pregnants with IUGR, reinforced by smoking, was revealed. We observed a decrease in the concentration of glutathione in blood and glutathione peroxidase activity in plasma and in erythrocyte lysate. A 4-fold higher metallothionein concentration in the plasma of women with IUGR in labour suggests that metallothionein may be one of the IUGR markers. Metallothionein concentration was intensified by smoking up to 7-fold in comparison to the controls. The pro/antioxidant balance during pregnancy is significantly affected by smoking. (C) 2011 Elsevier Inc. All rights reserved.
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收藏
页码：360 / 367
页数：8
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