Tris(oxazoline)/copper-catalyzed coupling of alkynes with nitrones: a highly enantioselective access to β-lactams

被引：34
作者：
Chen, Jiang-Hua [1 ]
Liao, Sai-Hu [2 ]
Sun, Xiu-Li [2 ]
Shen, Qi [1 ]
Tang, Yong [2 ]
机构：
[1] Suzhou Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth, Suzhou 215123, Jiangsu, Peoples R China
[2] Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
TETRAHEDRON | 2012年 / 68卷 / 25期
基金：
中国国家自然科学基金;
关键词：
Asymmetric catalysis; Kinugasa reaction; Trisoxazolines; beta-Lactams; Copper; FRIEDEL-CRAFTS REACTION; H INSERTION REACTIONS; ASYMMETRIC MICHAEL ADDITION; PSEUDO-C-3-SYMMETRIC TRISOXAZOLINE; KINETIC RESOLUTION; TERMINAL ALKYNES; TERNARY COMPLEX; ESTER ENOLATE; INDOLES; CONSTRUCTION;
D O I：
10.1016/j.tet.2012.04.049
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Chiral tris(oxazoline)/Cu(I) complexes are demonstrated as a type of efficient catalysts for the asymmetric Kinugasa reaction of terminal alkynes with C-arylnitrones, providing a highly enantio- and diastereoselective access to optically active beta-lactams. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5042 / 5045
页数：4
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