The brightness temperature fluctuations in the 21-cm background related to the neutral hydrogen distribution provide a probe of the physics related to the era of reionization, when the intergalactic medium changed from being completely neutral to partially ionized. We formulate statistics of 21-cm brightness temperature anisotropies in terms of the angular power spectrum, the bispectrum, and the trispectrum. Using the trispectrum, we estimate the covariance related to the power spectrum measurements and show that correlations resulting from non-Gaussianities are below a per cent, at most. While all-sky observations of the 21-cm background at arcminute-scale resolution can be used to measure the bispectrum with a cumulative signal-to-noise ratio of the order of a few tens, in the presence of foregrounds and instrumental noise related to first-generation interferometers, the measurement is unlikely to be feasible. For most purposes, non-Gaussianities in 21-cm fluctuations can be ignored and the distribution can be described with Gaussian statistics. Because 21-cm fluctuations are significantly contaminated by foregrounds, such as galactic synchrotron or low-frequency radio point sources, the lack of significant non-Gaussianity in the signal suggests that any significant detection of non-Gaussianity could be the result of foregrounds. Similarly, in addition to the frequency information that is now proposed to separate 21-cm fluctuations from foregrounds, if the non-Gaussian structure of foregrounds is known a priori, this additional information could potentially be used to reduce the confusion further.