RETRACTED: Asymmetric Synthesis of Apratoxin E (Retracted article. See vol. 82, pg. 11310, 2017)

被引：12

作者：

Mao, Zhuo-Ya ^{[1
,2
]}

Si, Chang-Mei ^{[1
]}

Liu, Yi-Wen ^{[2
]}

Dong, Han-Qing ^{[2
]}

Wei, Bang-Guo ^{[1
]}

Lin, Guo-Qiang ^{[1
,2
]}

机构：

[1] Fudan Univ, Sch Pharm, Dept Nat Prod Chem, 826 Zhangheng Rd, Shanghai 201203, Peoples R China

[2] Fudan Univ, Inst Biomed Sci, 130 Dongan Rd, Shanghai 200032, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 20期

基金：

中国国家自然科学基金;

关键词：

BIOLOGICAL EVALUATION; CONFORMATIONAL-ANALYSIS; OXAZOLINE ANALOG; NATURAL-PRODUCTS; CYCLODEPSIPEPTIDE; POTENT; LIPODEPSIPEPTIDES; COLLECTION; PROGRESS; PATHWAY;

D O I：

10.1021/acs.joc.6b02086

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for asymmetric synthesis of apratoxin E 2 is described in this report. The chiral lactone 8, recycled from the degradation of saponin glycosides, was utilized to prepare the non-peptide fragment 6. In addition to this "from nature to nature" strategy, olefin cross-metathesis (CM) was applied as an alternative approach for the formation of the double bond. Moreover, pentafluorophenyl diphenylphosphinate was found to be an efficient condensation reagent for the macrocyclization.

引用

页码：9903 / 9911

页数：9

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