Membrane Trafficking: An Endosome Tether Meets a Rab and Collapses

被引：3
作者：
Das, Sanchaita
Lambright, David G. [1 ]
机构：
[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA
来源：
CURRENT BIOLOGY | 2016年 / 26卷 / 20期
关键词：
AUTOANTIGEN; 1; EEA1; FUSION; ARCHITECTURE; DETERMINANTS; VESICLES; BINDING; DOCKING; PROTEIN; COMPLEX; FINGER;
D O I：
10.1016/j.cub.2016.08.056
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Long-range tethering is a ubiquitous recognition event preceding membrane fusion. A new study shows that Rab GTPase binding causes 'entropic collapse' of the coiled-coil endosome tether EEA1, driving membrane apposition and facilitating short-range interactions required for fusion.
引用
收藏
页码：R927 / R929
页数：3
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