Assessment of rewarding and reinforcing properties of biperiden in conditioned place preference in rats

被引：15
作者：
Allahverdiyev, Oruc [1 ]
Nurten, Asiye [2 ]
Enginar, Nurhan [1 ]
机构：
[1] Istanbul Univ, Dept Pharmacol & Clin Pharmacol, Istanbul Fac Med, Istanbul, Turkey
[2] Istanbul Univ, Dept Neurosci, Inst Expt Med DETAE, Istanbul, Turkey
来源：
BEHAVIOURAL BRAIN RESEARCH | 2011年 / 225卷 / 02期
关键词：
Biperiden; Morphine; Haloperidol; Abuse; Place preference; Reward; Reinforcement; ANTICHOLINERGIC DRUGS; MORPHINE; MICE; ABUSE; TRIHEXYPHENIDYL; RECEPTOR; SYSTEM; ANTAGONISTS; AVERSION; COCAINE;
D O I：
10.1016/j.bbr.2011.07.050
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Biperiden is one of the most commonly abused anticholinergic drugs. This study assessed its motivational effects in the acquisition of conditioned place preference in rats. Biperiden neither produced place conditioning itself nor enhanced the rewarding effect of morphine. Furthermore, biperiden in combination with haloperidol also did not affect place preference. These findings suggest that biperiden seems devoid of abuse potential properties at least at the doses used. (C) 2011 Elsevier B.V. All rights reserved.
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页码：642 / 645
页数：4
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