Antifungal and Antioxidant Activities of Pyrrolidone Thiosemicarbazone Complexes

被引：108

作者：

Al-Amiery, Ahmed A. ^{[1
,2
]}

Kadhum, Abdul Amir H. ^{[1
]}

Mohamad, Abu Bakar ^{[1
]}

机构：

[1] Univ Kebangsaan Malaysia, Fac Engn & Built Environm, Dept Chem & Proc Engn, Bangi 43600, Selangor, Malaysia

[2] Univ Technol Baghdad, Dept Appl Sci, Div Biotechnol, Baghdad 10066, Iraq

来源：

BIOINORGANIC CHEMISTRY AND APPLICATIONS | 2012年 / 2012卷

关键词：

TRANSITION-METAL-COMPLEXES; BIDENTATE SCHIFF-BASES; ANTIMICROBIAL ACTIVITY; ZN(II) COMPLEXES; ANTIBACTERIAL; CU(II); LIGAND; RUTHENIUM(II); QUERCETIN; EXTRACTS;

D O I：

10.1155/2012/795812

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metal complexes of (Z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide (L) with Cu(II), Co(II), and Ni(II) chlorides were tested against selected types of fungi and were found to have significant antifungal activities. The free-radical-scavenging ability of the metal complexes was determined by their interaction with the stable free radical 2,2 ''-diphenyl-1-picrylhydrazyl, and all the compounds showed encouraging antioxidant activities. DFT calculations of the Cu complex were performed using molecular structures with optimized geometries. Molecular orbital calculations provide a detailed description of the orbitals, including spatial characteristics, nodal patterns, and the contributions of individual atoms.

引用

页数：6

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