Research Advances in the Role of the Poly ADP Ribose Polymerase Family in Cancer

被引：4
|
作者：
Sha, Huanhuan [1 ]
Gan, Yujie [1 ]
Zou, Renrui [1 ]
Wu, Jianzhong [2 ]
Feng, Jifeng [1 ]
机构：
[1] Nanjing Med Univ, Jiangsu Canc Hosp, Jiangsu Inst Canc Res, Dept Chemotherapy,Affiliated Canc Hosp, Nanjing, Peoples R China
[2] Nanjing Med Univ, Jiangsu Canc Hosp, Jiangsu Inst Canc Res, Res Ctr Clin Oncol,Affiliated Canc Hosp, Nanjing, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
关键词：
PARPs; ADP-ribosylation; cancer; mechanism; biological process; ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; B-CELL LYMPHOMAS; BREAST-CANCER; POLY(ADP-RIBOSE) POLYMERASES; COLORECTAL-CANCER; MYELOID-LEUKEMIA; TUMOR-SUPPRESSOR; OVARIAN-CANCER; PARP6; ACTS;
D O I：
10.3389/fonc.2021.790967
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Poly ADP ribose polymerases (PARPs) catalyze the modification of acceptor proteins, DNA, or RNA with ADP-ribose, which plays an important role in maintaining genomic stability and regulating signaling pathways. The rapid development of PARP1/2 inhibitors for the treatment of ovarian and breast cancers has advanced research on other PARP family members for the treatment of cancer. This paper reviews the role of PARP family members (except PARP1/2 and tankyrases) in cancer and the underlying regulatory mechanisms, which will establish a molecular basis for the clinical application of PARPs in the future.
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收藏
页数：11
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