Use of Designer G Protein-Coupled Receptors to Dissect Metabolic Pathways

被引：14

作者：

Wess, Jurgen ^{[1
]}

机构：

[1] NIDDK, Mol Signaling Sect, Lab Bioorgan Chem, NIH, Bldg 8A,8 Ctr Dr MSC 0810, Bethesda, MD 20892 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2016年 / 27卷 / 09期

关键词：

G(Q)-COUPLED RECEPTOR; ACTIVATION; TARGETS; DREADDS; AGRP;

D O I：

10.1016/j.tem.2016.04.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

G protein-coupled receptors (GPCRs) regulate virtually all metabolic processes, including glucose and energy homeostasis. Recently, the use of designer GPCRs referred to as designer receptors exclusively activated by designer drug (DREADDs) has made it possible to dissect metabolically relevant GPCR signaling pathways in a temporally and spatially controlled fashion in vivo.

引用

页码：600 / 603

页数：4

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