Decrease of tyrosine hydroxylase-, α-synuclein- and parkin-expressing neurons in the substantia nigra of MPTP-treated C57BL/6N mice

被引：0

作者：

Kitamura, Y ^{[1
]}

Sanada, H

Kakimura, J

Ishida, Y

Shimohama, S

Taniguchi, T

机构：

[1] Kyoto Pharmaceut Univ, Dept Neurobiol, Kyoto 6078412, Japan

[2] Kyoto Univ, Grad Sch Med, Dept Neurol, Kyoto 6068501, Japan

来源：

BIOGENIC AMINES | 2001年 / 16卷 / 02期

关键词：

MPTP; alpha-synuclein; parkin; tyrosine hydroxylase; substantia nigra; C57BL/6N mouse;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, mutations in the alpha -synuclein (PARK1) and parkin (PARK2) genes have been identified from patients with the familial Parkinson's disease and parkinsonism, respectively. Systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is known to damage the nigrostriatal dopaminergic system in C57BL/6 mice, in this study, we have investigated changes of immunoreactivities for alpha -synuclein, parkin and tyrosine hydroxylase (TH) in MPTP-treated C57BL/6N mouse brains. Immunoreactivities for alpha -synuclein, parkin and TH were differentially distributed in the mouse brain. MPTP treatment caused significant decrease of the number of TH-, alpha -synuclein- and parkin-immunopositive neurons in the substantia nigra, although these immunoreactivities were not markedly changed in the striatum. These results suggest that alpha -synuclein and parkin may participate in MPTP-induced dopaminergic neurodegeneration in the substantia nigra.

引用

页码：127 / 136

页数：10

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