Activation cross sections for proton induced reactions on Sm are presented for the first time for (nat)sm(p,xn)Eu-154,Eu-152m2,Eu-152m1,Eu-152g,Eu-150m,Eu-150g,Eu-149,Eu-148,Eu-147,Eu-146,Eu-145, (nat)sm(m)(153,145)sm, (nat)sm(p,x)Pm-151,Pm-150,Pm-149,Pm-148g,Pm-148m,Pm-146,Pm-144.143 and (nat)sm(p,x)Nd-141 up to 65 MeV. The cross sections were measured via activation method by using a stacked-foil irradiation technique and high resolution gamma ray spectroscopy. The results were compared with results of the nuclear reaction codes ALICE, EMPIRE and TALYS (results taken from TENDL libraries). Integral yields of the activation products were calculated from the excitation functions. (C) 2015 Elsevier B.V. All rights reserved.