Role of Aldynoglia Cells in Neuroinflammatory and Neuroimmune Responses after Spinal Cord Injury

被引：3

作者：

Buzoianu-Anguiano, Vinnitsa ^{[1
]}

Torres-Llacsa, Mabel ^{[2
]}

Doncel-Perez, Ernesto ^{[1
]}

机构：

[1] Hosp Nacl Paraplej, SESCAM, Grp Quim Neuro Regenerat, Toledo 45071, Spain

[2] Hosp Nacl Paraplej, Serv Radiol, SESCAM, Toledo 45071, Spain

来源：

CELLS | 2021年 / 10卷 / 10期

关键词：

aldynoglia; axonal growth; bdnf; ensheathing cells; epscs; gfap; macrophage; microglia; p75; ngfr; sci; vimentin; HUMAN PINEAL-GLAND; STEM-CELLS; POLARIZED MACROPHAGES; FUNCTIONAL RECOVERY; BERGMANN GLIA; DIFFERENTIATION; CNS; IMMUNOREACTIVITY; REGENERATION; PROGENITORS;

D O I：

10.1111/j.1768-322X.2004.tb01416.x; 10.3390/cells10102783

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aldynoglia are growth-promoting cells with a morphology similar to radial glia and share properties and markers with astrocytes and Schwann cells. They are distributed in several locations throughout the adult central nervous system, where the cells of the aldynoglia interact and respond to the signals of the immune cells. After spinal cord injury (SCI), the functions of resident aldynoglia, identified as ependymocytes, tanycytes, and ependymal stem cells (EpSCs) of the spinal cord are crucial for the regeneration of spinal neural tissue. These glial cells facilitate axonal regrowth and remyelination of injured axons. Here, we review the influence of M1 or M2 macrophage/microglia subpopulations on the fate of EpSCs during neuroinflammation and immune responses in the acute, subacute, and chronic phases after SCI.</p>

引用

页数：14

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