Pd(II)-Catalyzed P(O)R1R2-Directed Asymmetric C-H Activation and Dynamic Kinetic Resolution for the Synthesis of Chiral Biaryl Phosphates

被引：117

作者：

Ma, Yan-Na ^{[1
]}

Zhang, Hong-Yu ^{[1
]}

Yang, Shang-Dong ^{[1
,2
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 08期

关键词：

ENANTIOSELECTIVE SYNTHESIS; PHOSPHORUS LIGANDS; BOND; HYDROXYLATION; ALKENYLATION; SUBSTITUTION; OLEFINATION; IODINATION; ALKYLATION; COMPLEXES;

D O I：

10.1021/acs.orglett.5b00844

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method of Pd(II)-catalyzed P(O)-(RR2)-R-1-directed asymmetric C-H activation and dynamic kinetic resolution for synthesis of chiral phosphinate ligands has been performed and exhibits a wide scope of substrates and an excellent diastereomeric ratio (>95:5).

引用

页码：2034 / 2037

页数：4

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