According to the requirements for the teaching reform and innovation of art courses in colleges and universities in China, this paper takes the "Clothing Materials" course of fashion design major as an example to establish an application-oriented teaching system of "theory learning plus market research plus fabric analysis and innovation re-engineering" centering on the cultivation of students' practical ability and innovative ability with the market demand as orientation through integrating the curriculum structure, adjusting teaching methods, and reforming teaching content and evaluation system.