Toll-like receptor activation in immunity vs. tolerance in autoimmune diabetes

被引:15
作者
Guelden, Elke [1 ]
Wen, Li [1 ]
机构
[1] Yale Univ, Sch Med, Endocrinol Sect, New Haven, CT 06520 USA
关键词
Toll-like receptors; type; 1; diabetes; immunity; tolerance; regulatoryT-cells; REGULATORY T-CELLS; BETA-CELLS; INTESTINAL MICROBIOTA; MEDIATED SUPPRESSION; INNATE IMMUNITY; NOD MICE; TLR2; EXPRESSION; SELF; LIPOPOLYSACCHARIDE;
D O I
10.3389/fimmu.2014.00119
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
[No abstract available]
引用
收藏
页数:5
相关论文
共 54 条
[1]   Toll-like receptors: critical proteins linking innate and acquired immunity [J].
Akira, S ;
Takeda, K ;
Kaisho, T .
NATURE IMMUNOLOGY, 2001, 2 (08) :675-680
[2]   Pam3CSK4 enhanced beta cell loss and diabetogenesis: The roles of IFN-gamma and IL-17 [J].
Al Shamsi, Mariam ;
Shahin, Allen ;
Iwakura, Yoichiro ;
Lukic, Miodrag L. ;
Mensah-Brown, Eric P. K. .
CLINICAL IMMUNOLOGY, 2013, 149 (01) :86-96
[3]   The apoptotic signaling pathway activated by Toll-like receptor-2 [J].
Aliprantis, AO ;
Yang, RB ;
Weiss, DS ;
Godowski, P ;
Zychlinsky, A .
EMBO JOURNAL, 2000, 19 (13) :3325-3336
[4]  
Alyanakian MA, 2006, DIABETES, V55, P179, DOI 10.2337/diabetes.55.01.06.db05-0189
[5]   TLR2 ligation protects effector T cells from regulatory T-cell mediated suppression and repolarizes T helper responses following MVA-based cancer immunotherapy [J].
Amiset, Laurent ;
Fend, Laetitia ;
Gatard-Scheikl, Tania ;
Rittner, Karola ;
Duong, Vanessa ;
Rooke, Ronald ;
Muller, Sylviane ;
Bonnefoy, Jean-Yves ;
Preville, Xavier ;
Haegel, Helene .
ONCOIMMUNOLOGY, 2012, 1 (08) :1271-1280
[6]   Systemic Toll-Like Receptor Stimulation Suppresses Experimental Allergic Asthma and Autoimmune Diabetes in NOD Mice [J].
Aumeunier, Aude ;
Grela, Francoise ;
Ramadan, Abdulraouf ;
Linh Pham Van ;
Bardel, Emilie ;
Alcala, Alejandro Gomez ;
Jeannin, Pascale ;
Akira, Shizuo ;
Bach, Jean-Francois ;
Thieblemont, Nathalie .
PLOS ONE, 2010, 5 (07)
[7]   The Hygiene Hypothesis: An Explanation for the Increased Frequency of Insulin-Dependent Diabetes [J].
Bach, Jean-Francois ;
Chatenoud, Lucienne .
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2012, 2 (02)
[8]   Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide [J].
Caramalho, I ;
Lopes-Carvalho, T ;
Ostler, D ;
Zelenay, S ;
Haury, M ;
Demengeot, J .
JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (04) :403-411
[9]   Endotoxin tolerance: is there a clinical relevance? [J].
Cavaillon, JM ;
Adrie, C ;
Fitting, C ;
Adib-Conquy, M .
JOURNAL OF ENDOTOXIN RESEARCH, 2003, 9 (02) :101-107
[10]   Identification of IL-1β-induced messenger RNAs in rat pancreatic beta cells by differential display of messenger RNA [J].
Chen, MC ;
Schuit, F ;
Eizirik, DL .
DIABETOLOGIA, 1999, 42 (10) :1199-1203