Nonsmall cell lung carcinoma: diagnostic difficulties in small biopsies and cytological specimens

被引：65
作者：
Bubendorf, Lukas [1 ]
Lantuejoul, Sylvie [2 ,3 ]
de langen, Adrianus J. [4 ]
Thunnissen, Erik [5 ]
机构：
[1] Univ Basel, Inst Pathol, Basel, Switzerland
[2] UNICANCER, Ctr Leon Berard, Dept Biopathol, Lyon, France
[3] Grenoble Alpes Univ, CNRS 5309, INSERM, Inst Adv Biosci,U1209, Grenoble, France
[4] Vrije Univ Amsterdam Med Ctr, Dept Resp Dis, Amsterdam, Netherlands
[5] Vrije Univ Amsterdam Med Ctr, Dept Pathol, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands
来源：
EUROPEAN RESPIRATORY REVIEW | 2017年 / 26卷 / 144期
关键词：
IN-SITU HYBRIDIZATION; MOLECULAR TESTING GUIDELINE; OF-AMERICAN-PATHOLOGISTS; ALK GENE REARRANGEMENT; ROS1; REARRANGEMENTS; PHASE-III; ONCOGENE MUTATIONS; PD-L1; EXPRESSION; CANCER PATIENTS; OPEN-LABEL;
D O I：
10.1183/16000617.0007-2017
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
The pathological and molecular classification of lung cancer has become substantially more complex over the past decade. For diagnostic purposes on small samples, additional stains are frequently required to distinguish between squamous cell carcinoma and adenocarcinoma. Subsequently, for advanced nonsquamous cell nonsmall cell lung carcinoma (NSCLC) patients, predictive analyses on epidermal growth factor receptor, anaplastic lymphoma kinase and ROS1 are required. In NSCLCs negative for these biomarkers, programmed death ligand-1 immunohistochemistry is performed. Small samples (biopsy and cytology) require " tissue" management, which is best achieved by the interaction of all physicians involved.
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页数：15
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