Combinatorial synthesis of 4-oxo-4H-imidazo[1,5-a]quinoxalines and 4-oxo-4H-pyrazolo[1,5-a]quinoxalines

被引：20

作者：

Spatz, Julia H. ^{[1
,2
]}

Umkehrer, Michael ^{[1
]}

Kalinski, Cedric ^{[1
]}

Ross, Guenther ^{[1
]}

Burdack, Christoph ^{[1
]}

Kolb, Juergen ^{[1
]}

Bach, Thorsten ^{[2
]}

机构：

[1] Priaton GmbH, D-81739 Munich, Germany

[2] Tech Univ Munich, D-85747 Garching, Germany

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 45期

关键词：

Ugi-reaction; multi-component reaction; imidazo-quinoxaline; pyrazolo-quinoxaline; nucleophilic aromatic substitution;

D O I：

10.1016/j.tetlet.2007.09.015

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A combinatorial synthetic route yielding imidazo[1,5-a]quinoxalines and pyrazolo[1,5-a] quinoxalines is described. The use of 2-fluoroaniline and 1H-imidazole-4-carboxylic acid, respectively, 1H-pyrazole-3-carboxylic acid in the Ugi-reaction (U-4CR) followed by a nucleophilic aromatic substitution (S(N)Ar) affords the imidazo- as well as the pyrazolo-[1,5-a] quinoxaline moiety in good yield and high diversity. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：8060 / 8064

页数：5

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