Angiotensin-Converting Enzyme Gene Polymorphism in Children with Idiopathic Nephrotic Syndrome, Effect on Biopsy Findings

被引：0

作者：

Monajemzadeh, Maryam ^{[1
]}

Hesami, Mahshid ^{[1
]}

Shahsiah, Reza ^{[1
]}

Vasei, Mohammad ^{[1
]}

Hooshmand, Safoora ^{[1
]}

Tanzifi, Parin ^{[1
]}

Hajizadeh, Niloofar ^{[1
]}

Ataei, Neamatollah ^{[1
]}

Mehrkash, Mehryar ^{[1
]}

Larijani, Faezeh Javadi ^{[1
]}

Moghtaderi, Mastaneh ^{[1
]}

Bazargani, Behnaz ^{[1
]}

Khorvash, Reza ^{[1
]}

Soleimanifar, Narjes ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Pathol, Tehran, Iran

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2017年 / 36卷 / 04期

关键词：

Angiotensin converting enzyme; ACE I/D gene polymorphism; idiopathic nephrotic syndrome; real time PCR; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; INSERTION/DELETION POLYMORPHISM; IGA NEPHROPATHY; PULSE METHYLPREDNISOLONE; SYSTEM; METAANALYSIS; ASSOCIATION; PROGRESSION; GENOTYPE; RISK;

D O I：

10.1080/15513815.2017.1287229

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objective: Angiotensin converting enzyme (ACE) converts angiotensin I into angiotensin II. The ACE gene shows an I/D polymorphism, which correlates with ACE concentrations. The aim of this study is to evaluate the distribution of the ACE I/D genotype in children with idiopathic nephrotic syndrome (INS) and healthy controls and study the effect of this polymorphism on clinical and pathologic findings. Methods: ACE gene I/D polymorphism of 104 patients with INS and 119 controls were determined. Results: The DD, ID, and II genotypes were found in 58.7%, 22.1%, and 19.2% of the patients, and in 79.8%, 2.5%, and 17.6% of controls, respectively (p > 0.05). The ID genotype was seen more frequently in patients resistant to treatment. Conclusion: The observed differences with previous reports suggest the influence of the genetic background on disease course. The ACE I/D gene polymorphism's role seems to be more important in renal disease progression than susceptibility.

引用

页码：265 / 275

页数：11

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