Directed evolution for drug and nucleic acid delivery

被引：24

作者：

Hida, Kaoru ^{[1
]}

Hanes, Justin ^{[1
,2
,3
]}

Ostermeier, Marc ^{[2
,3
]}

机构：

[1] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA

[3] Johns Hopkins Univ, Inst NanoBioTechnol Johns Hopkins, Baltimore, MD 21218 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2007年 / 59卷 / 15期

关键词：

molecular evolution; directed evolution; antibody affinity maturation; viral gene therapy; ADEPT; GDEPT;

D O I：

10.1016/j.addr.2007.08.022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Directed evolution is a term used to describe a variety of related techniques to rapidly evolve peptides and proteins into new forms that exhibit improved properties for specific applications. In this process, molecular biology techniques allow the creation of up to billions of mutants in a single experiment, which are then subjected to high-throughput screening to identify those with enhanced activity. Applications of directed evolution to drug and gene delivery have been recently described, including those that improve the effectiveness of therapeutic enzymes, targeting peptides and antibodies, and the effectiveness or tropism of viral vectors for use in gene therapy. This review first introduces fundamental concepts of directed evolution, and then discusses emerging applications in the field of drug and gene delivery. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：1562 / 1578

页数：17

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