Prognostic Value of KRAS Mutations in the Peripheral Blood of Patients with Pancreatic Cancer: a Systematic Review and Meta-analysis

被引:0
|
作者
Li, Weiwei [1 ]
Zhang, Xuejun [1 ]
Li, Yanhua [2 ]
Yue, Qiuju [1 ]
Cui, Miaohang [1 ]
Liu, Jinlong [1 ]
机构
[1] Chengde Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Chengde, Hebei, Peoples R China
[2] Kuancheng Manchu Autonomous Cty Hosp, Gen Surg, Chengde, Hebei, Peoples R China
关键词
KRAS mutations; Peripheral blood; Pancreatic cancer; Prognosis; Meta-analysis; CIRCULATING TUMOR DNA; SENSITIVE MARKER; PLASMA; CHEMOTHERAPY; GEMCITABINE; RESECTION; CELLS;
D O I
10.1007/s12262-021-03142-0
中图分类号
R61 [外科手术学];
学科分类号
摘要
KRAS mutations are common in patients with pancreatic cancer. However, the prognostic significance of KRAS mutations in peripheral blood of pancreatic cancer patients remains uncertain. Thus, this meta-analysis was conducted to assess the prognostic value of KRAS mutations in peripheral blood samples of these patients. We conducted a comprehensive search of articles listed in the PubMed, EMBASE literature databases, and Web of Science databases. The search covered the publication period from database inception to October 10, 2020. Twenty-eight studies met the inclusion criteria and 2,006 patients were pooled for the meta-analysis. The average positive rate of KRAS mutations in peripheral blood was 44.9%. Our meta-analysis indicated that KRAS mutations in peripheral blood have a negative prognostic value in pancreatic cancer [hazard ratio (HR), 2.42; 95% confidence interval (CI), 1.95-3.01]. Moreover, further subgroup analyses by stages of pancreatic cancer and KRAS target mutations all revealed that pancreatic cancer patients with the KRAS mutations had inferior overall survival. KRAS mutations in peripheral blood have a negative prognostic value in pancreatic cancer.
引用
收藏
页码:476 / 484
页数:9
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