Behavior of vascular endothelial growth factor and erythropoietin throughout the menstrual cycle in healthy women

被引:0
作者
Caccamo, Chiara
Nostro, Lorena
Giorgianni, Giovanna
Mondello, Stefania
Crasci, Eleonora
Frisina, Nicola
Buemi, Michele
机构
[1] Univ Messina, Dept Internal Med, Chair Nephrol, Messina, Italy
[2] Univ Messina, Dept Clin Biochem, Chair Nephrol, Messina, Italy
关键词
erythropoietin; menstrual cycle; vascular endothelial growth factor;
D O I
暂无
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: To evaluate any correlations between erythropoietin (EPO) and vascular endothelial growth factor (VEGF) levels in the serum and the menstrual fluid of healthy women during the different phases of the menstrual cycle. STUDY DESIGN: Blood samples from 25 healthy female volunteers were obtained for serum VEGF and EPO detection on the 1st, 7th, 14th, 21st and 25th days of the menstrual cycle. Menstrual fluid samples for VEGF and EPO detection were obtained on the 1st and 4th days of menstruation. RESULTS: Circulating VEGF levels were found to increase in a stage-dependent cyclic manner. The mean VEGF concentration in menstrual blood on the 1st day of the cycle was significantly higher than the mean plasma value and was reduced to a significant extent on the 4th day of the cycle. We found no significant changes in serum EPO levels. Mean EPO concentration detected in menstrual blood was comparable to those in serum blood either on the 1st or 4th day of the menstrual cycle. CONCLUSION. During menstruation, a local production of VEGF occurs independent of systemic production, thus sustaining angiogenic activity in autonomous, independent ways. Our findings demonstrate the presence of an ''open compartment'' that reflects the systemic pattern of EPO at the uterine level that allows us to speculate on different effects beyond the angiogenic action of EPO.
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收藏
页码:1035 / 1039
页数:5
相关论文
共 30 条
  • [1] Serum vascular endothelial growth factor (VEGF) in the normal menstrual cycle: association with changes in ovarian and uterine Doppler blood flow
    Agrawal, R
    Conway, GS
    Sladkevicius, P
    Payne, NN
    Bekir, J
    Campbell, S
    Tan, SL
    Jacobs, HS
    [J]. CLINICAL ENDOCRINOLOGY, 1999, 50 (01) : 101 - 106
  • [2] BAUSERO P, 1998, ANGIOGENESIS, V2, P67
  • [3] BLOBEL GA, 1995, MOL CELL BIOL, V15, P3147
  • [4] Recombinant human erythropoietin stimulates angiogenesis and healing of ischemic skin wounds
    Buemi, M
    Galeano, M
    Sturiale, A
    Ientile, R
    Crisafulli, C
    Parisi, A
    Catania, MA
    Calapai, G
    Impalà, P
    Aloisi, C
    Squadrito, F
    Altavilla, D
    Bitto, A
    Tuccari, G
    Frisina, N
    [J]. SHOCK, 2004, 22 (02): : 169 - 173
  • [5] Hemodynamic effects of recombinant human erythropoietin
    Buemi, M
    Allegra, A
    Aloisi, C
    Corica, F
    Frisina, N
    [J]. NEPHRON, 1999, 81 (01) : 1 - 4
  • [6] Buemi M, 2002, J NEPHROL, V15, P97
  • [7] Tissue-specific regulation of erythropoietin production in the murine kidney, brain, and uterus
    Chikuma, M
    Masuda, S
    Kobayashi, T
    Nagao, M
    Sasaki, R
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2000, 279 (06): : E1242 - E1248
  • [8] VASCULAR-PERMEABILITY FACTOR - A UNIQUE REGULATOR OF BLOOD-VESSEL FUNCTION
    CONNOLLY, DT
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 1991, 47 (03) : 219 - 223
  • [9] The biology of vascular endothelial growth factor
    Ferrara, N
    DavisSmyth, T
    [J]. ENDOCRINE REVIEWS, 1997, 18 (01) : 4 - 25
  • [10] Focal vascular endothelial growth factor correlates with angiogenesis in human endometrium. Role of intravascular neutrophils
    Gargett, CE
    Lederman, F
    Heryanto, B
    Gambino, LS
    Rogers, PAW
    [J]. HUMAN REPRODUCTION, 2001, 16 (06) : 1065 - 1075