Report of an International collaborative study to establish the first WHO reference reagents for BCG vaccines of three different sub-strains

被引：14

作者：

Ho, Mei M. ^{[1
]}

Markey, Kevin ^{[1
]}

Rigsby, Peter

Hockley, Jason

Corbel, Michael J. ^{[1
]}

机构：

[1] NIBSC HPA, Bacteriol Div, Potters Bar EN6 3QG, Herts, England

来源：

VACCINE | 2011年 / 29卷 / 03期

关键词：

WHO; Reference Reagent; BCG; MULTIPLEX PCR; SUITABILITY; ASSAY;

D O I：

10.1016/j.vaccine.2010.10.066

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The WHO First International Reference Preparation for BCG vaccine is over forty years old and is no longer available for distribution due to stock depletion and its significant loss of viability. International consultations identified a demand for replacement with sub-strain specific BCG preparations. An International collaborative study was carried out to evaluate three candidates for WHO Reference Reagent for BCG vaccine of Danish 1331, Russian BCG-1 and Tokyo 172-1 sub-strains. These candidates were quantified for viability using both cultural viable count and modified ATP assays. The proposal for the establishment of these First WHO Reference Reagents for BCG vaccines was discussed in the WHO Expert Committee on Biological Standardization meeting, October 2009. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：512 / 518

页数：7

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