Influence of inflammatory bowel disease on different dimensions of quality of life

Objective To establish the impairment of different dimensions of quality of life in inflammatory bowel disease (IBD). Design Prospective observational study. Participants 289 patients [160 with ulcerative colitis (UC) and 129 with Crohn's disease (CD)]. Measures Health-related quality of life was assessed by means of the Inflammatory Bowel Disease Questionnaire (IBDQ) and the Psychological General Well Being Index (PGWBI). Results In active IBD, all dimensions of the quality of life scored significantly lower than in inactive IBD, indicating a poor quality of life. Social impairment was the least impaired dimension of the IBDQ in active UC and CD, compared with digestive and systemic symptoms. In inactive IBD, the systemic symptoms domain received the lowest score (P < 0.01). In a subgroup of 22 patients studied before and after remission, emotional function was the most impaired dimension after achieving remission. The Psychological General Well Being Index was significantly impaired in active UC [78.5 (range 64-89)] and CD [76.5 (range 69-97)] relative inactive IBD [104 (range 93-111)] vs 106 (95-113), respectively; P < 0.05]. Conclusions Quality of life is impaired in IBD. During relapse, clinicians should pay attention to digestive symptoms and psychological distress. In remission, they should be sensitive to systemic symptoms. Eur J Gastroenterol Hepatol 13:567-572 (C) 2001 Lippincott Williams & Wilkins.