Pulmonary Vascular and Right Ventricular Reserve in Patients With Normalized Resting Hemodynamics After Pulmonary Endarterectomy

被引：87

作者：

Claessen, Guido ^{[1
,5
]}

La Gerche, Andre ^{[1
,4
,5
]}

Dymarkowski, Steven ^{[2
,6
]}

Claus, Piet ^{[5
]}

Delcroix, Marion ^{[3
,7
]}

Heidbuchel, Hein ^{[8
,9
]}

机构：

[1] Katholieke Univ Leuven Hosp, Dept Cardiovasc Med, B-3000 Louvain, Belgium

[2] Katholieke Univ Leuven Hosp, Dept Radiol, B-3000 Louvain, Belgium

[3] Katholieke Univ Leuven Hosp, Dept Pneumol, B-3000 Louvain, Belgium

[4] Univ Melbourne, St Vincents Hosp, Dept Internal Med, Fitzroy, Vic 3065, Australia

[5] Katholieke Univ Leuven, Dept Cardiovasc Sci, Leuven, Belgium

[6] Katholieke Univ Leuven, Dept Imaging & Pathol, Leuven, Belgium

[7] Katholieke Univ Leuven, Dept Clin & Expt Med, Leuven, Belgium

[8] Hasselt Univ, Hasselt, Belgium

[9] Jessa Hosp, Ctr Heart, Hasselt, Belgium

来源：

JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2015年 / 4卷 / 03期

基金：

英国医学研究理事会;

关键词：

cardiac magnetic resonance imaging; chronic thromboembolic pulmonary hypertension; exercise; pulmonary; arterial compliance; pulmonary vascular resistance; right ventricle; ARTERIAL-HYPERTENSION; HEART-RATE; EXERCISE; THROMBOENDARTERECTOMY; PRESSURE; CIRCULATION; RESISTANCE; LEVEL; MEN;

D O I：

10.1161/JAHA.114.001602

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background-Patients with normalized mean pulmonary artery pressure (mPAP) after pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH) do not always regain normal exercise capacity. We evaluated right ventricular function, its interaction with both pulsatile and resistive afterload, and the effect of sildenafil during exercise in these patients. Methods and Results-Fourteen healthy controls, 15 CTEPH patients, and 7 patients with normalized resting mPAP (<= 25 mm Hg) post-PEA underwent cardiopulmonary exercise testing, followed by cardiac magnetic resonance imaging with simultaneous invasive mPAP measurement during incremental supine cycling exercise. Peak oxygen consumption and peak heart rate were significantly reduced in post-PEA and CTEPH patients compared to controls. The mPAP cardiac output slope was steeper in post-PEA patients than in controls and similar to CTEPH. Relative to controls, resting right ventricular ejection fraction was reduced in CTEPH, but not in post-PEA patients. In contrast, peak exercise right ventricular ejection fraction was reduced both in post-PEA and CTEPH patients. Exercise led to reduction of pulmonary arterial compliance in all groups. Nevertheless, resting pulmonary arterial compliance values in CTEPH and post-PEA patients were even lower than those in controls at peak exercise. In post-PEA patients, sildenafil did not affect resting hemodynamics nor right ventricular function, but decreased the mPAP/cardiac output slope and increased peak exercise right ventricular ejection fraction. Conclusions-Exercise intolerance in post-PEA patients is explained by abnormal pulmonary vascular reserve and chronotropic incompetence. The mPAP/cardiac output slope and pulmonary arterial compliance are sensitive measures demonstrating abnormal resistive and pulsatile pulmonary vascular function in post-PEA patients. These abnormalities are partially attenuated with sildenafil.

引用

页数：16