A 64-year-old female patient with recurring hypoglycaemia

被引：1

作者：

Hunger-Dathe, W. ^{[1
]}

Hocke, M.

Saemann, A.

Mueller, U. A.

Wolf, G.

Gajda, M.

机构：

[1] Univ Jena, Innere Med Klin 3, Jena, Germany

[2] Univ Jena, Innere Med Klin 2, D-6900 Jena, Germany

[3] Univ Jena, Inst Pathol, D-6900 Jena, Germany

来源：

INTERNIST | 2007年 / 48卷 / 09期

关键词：

insulinoma; split insulin; endoscopic ultrasonography;

D O I：

10.1007/s00108-007-1924-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulinomas are the most common pancreatic islet cell tumours and are characterised by uncontrolled insulin secretion even in the presence of hypoglycaemia. Diagnosis is usually made by the detection of endogenous hyperinsulinism over a period of fasting. We report the case of a patient with insulinoma without hyperinsulinaemia. A secretion and overexpression of split insulin has to be discussed. The diagnosis was made by endoscopic ultrasound-guided fine-needle aspiration and the immunohistochemical detection of chromogranine. In conclusion, the present report demonstrates that insulinomas should be considered and searched for in every case of hypoglycaemia, even when associated with normal insulin levels. It also confirms the essential role of endoscopic ultrasonography in the diagnosis of insulin-secreting tumors.

引用

页码：1020 / +

页数：8

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