Influence of 516G>T polymorphisms at the gene encoding the CYP450-2B6 isoenzyme on efavirenz plasma concentrations in HIV-infected subjects

被引：149
作者：
Rodriguez-Novoa, S
Barreiro, P
Rendón, A
Jiménez-Nacher, I
González-Lahoz, J
Soriano, V
机构：
[1] Hosp Carlos III, Pharmacokinet Unit, Madrid, Spain
[2] Hosp Carlos III, Infect Dis Serv, Madrid, Spain
来源：
CLINICAL INFECTIOUS DISEASES | 2005年 / 40卷 / 09期
关键词：
D O I：
10.1086/429327
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We examined 516G>T polymorphisms at the gene encoding the cytochrome P450 in 100 human immunodeficiency virus positive subjects who were receiving efavirenz (EFV). Elevated plasma EFV concentrations were found in 40% of subjects with the polymorphic homozygous genotype and 19% of subjects with the heterozygous genotype. Conversely, 20% of subjects with the wild-type genotype had subtherapeutic concentrations of EFV. CYP2B6-516 genotyping may help to identify subjects who have plasma EFV concentrations that are outside of the therapeutic range.
引用
收藏
页码：1358 / 1361
页数：4
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