Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes?

被引:172
作者
Celli, Jean [1 ]
Tsolis, Renee M. [2 ]
机构
[1] Washington State Univ, Coll Vet Med, Paul G Allen Sch Global Anim Hlth, Pullman, WA 99164 USA
[2] Univ Calif Davis, Sch Med, Dept Med Microbiol & Immunol, Davis, CA 95616 USA
关键词
INNATE IMMUNE-RESPONSES; THIOREDOXIN-INTERACTING PROTEIN; QUALITY-CONTROL PROTEINS; LEGIONELLA-PNEUMOPHILA; SUBTILASE CYTOTOXIN; BRUCELLA-ABORTUS; SECRETION SYSTEMS; INTRACELLULAR REPLICATION; ACTIVATES TRANSCRIPTION; TRANSMEMBRANE PROTEIN;
D O I
10.1038/nrmicro3393
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The unfolded protein response (UPR) is a cytoprotective response that is aimed at restoring cellular homeostasis following physiological stress exerted on the endoplasmic reticulum (ER), which also invokes innate immune signalling in response to invading microorganisms. Although it has been known for some time that the UPR is modulated by various viruses, recent evidence indicates that it also has multiple roles during bacterial infections. In this Review, we describe how bacteria interact with the ER, including how bacteria induce the UPR, how subversion of the UPR promotes bacterial proliferation and how the UPR contributes to innate immune responses against invading bacteria.
引用
收藏
页码:71 / 82
页数:12
相关论文
共 127 条
[1]   ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum [J].
Adachi, Yusuke ;
Yamamoto, Keisuke ;
Okada, Tetsuya ;
Yoshida, Hiderou ;
Harada, Akihiro ;
Mori, Kazutoshi .
CELL STRUCTURE AND FUNCTION, 2008, 33 (01) :75-89
[2]   Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis [J].
Akazawa, Yuko ;
Isomoto, Hajime ;
Matsushima, Kayoko ;
Kanda, Tsutomu ;
Minami, Hitomi ;
Yamaghchi, Naoyuki ;
Taura, Naota ;
Shiozawa, Ken ;
Ohnita, Ken ;
Takeshima, Fuminao ;
Nakano, Masayuki ;
Moss, Joel ;
Hirayama, Toshiya ;
Nakao, Kazuhiko .
PLOS ONE, 2013, 8 (12)
[3]   The Legionella pneumophila Effector DrrA Is Sufficient to Stimulate SNARE-Dependent Membrane Fusion [J].
Arasaki, Kohei ;
Toomre, Derek K. ;
Roy, Craig R. .
CELL HOST & MICROBE, 2012, 11 (01) :46-57
[4]   Legionella pneumophila Promotes Functional Interactions between Plasma Membrane Syntaxins and Sec22b [J].
Arasaki, Kohei ;
Roy, Craig R. .
TRAFFIC, 2010, 11 (05) :587-600
[5]   Early trafficking and intracellular replication of Legionella longbeachaea within an ER-derived late endosome-like phagosome [J].
Asare, Rexford ;
Abu Kwaik, Yousef .
CELLULAR MICROBIOLOGY, 2007, 9 (06) :1571-1587
[6]   The unfolded protein response is activated in Helicobacter-induced gastric carcinogenesis in a non-cell autonomous manner [J].
Baird, Mhairi ;
Ang, Pei Woon ;
Clark, Ian ;
Bishop, Danial ;
Oshima, Masanobu ;
Cook, Matthew C. ;
Hemmings, Christine ;
Takeishi, Shigeo ;
Worthley, Dan ;
Boussioutas, Alex ;
Wang, Timothy C. ;
Taupin, Doug .
LABORATORY INVESTIGATION, 2013, 93 (01) :112-122
[7]   COPII - A MEMBRANE COAT FORMED BY SEC PROTEINS THAT DRIVE VESICLE BUDDING FROM THE ENDOPLASMIC-RETICULUM [J].
BARLOWE, C ;
ORCI, L ;
YEUNG, T ;
HOSOBUCHI, M ;
HAMAMOTO, S ;
SALAMA, N ;
REXACH, MF ;
RAVAZZOLA, M ;
AMHERDT, M ;
SCHEKMAN, R .
CELL, 1994, 77 (06) :895-907
[8]   Brucella abortus Uses a Stealthy Strategy to Avoid Activation of the Innate Immune System during the Onset of Infection [J].
Barquero-Calvo, Elias ;
Chaves-Olarte, Esteban ;
Weiss, David S. ;
Guzman-Verri, Caterina ;
Chacon-Diaz, Carlos ;
Rucavado, Alexandra ;
Moriyon, Ignacio ;
Moreno, Edgardo .
PLOS ONE, 2007, 2 (07)
[9]   Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response [J].
Bernales, Sebastian ;
McDonald, Kent L. ;
Walter, Peter .
PLOS BIOLOGY, 2006, 4 (12) :2311-2324
[10]   Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response [J].
Bertolotti, A ;
Zhang, YH ;
Hendershot, LM ;
Harding, HP ;
Ron, D .
NATURE CELL BIOLOGY, 2000, 2 (06) :326-332