Catalytic enantioselective fluorination of α-cyano acetates catalyzed by chiral palladium complexes

被引：115

作者：

Kim, HR ^{[1
]}

Kim, DY ^{[1
]}

机构：

[1] Soonchunhyang Univ, Dept Chem, Chungnam 336600, South Korea

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 17期

关键词：

chiral palladium complexes; fluorination; asymmetric reactions;

D O I：

10.1016/j.tetlet.2005.02.164

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The catalytic enantioselective electrophilic fluorination promoted chiral palladium complexes is described. Treatment of alpha-cyano acetates with N-fluorobenzenesulfonimide as the fluorine source under mild reaction conditions afforded the corresponding alpha-cyano alpha-fluoro acetates in high yields with excellent enantiomeric excesses (85-99% ee). (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3115 / 3117

页数：3

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